The Cancer Etiology Branch (CEB) supports research programs dealing with biological, chemical, and physical agents that are possible etiological factors or co-factors in cancer, with the control of these agents and their associated diseases, and with the contribution of the host genome, proteome and microbiome to the sensitivity of cells, tissues and organs to these agents. Studies supported by the Branch fall into two broad categories. Studies of Biological Carcinogenesis deal with biologic agents (primarily viruses and bacteria) as etiologic agents in malignancy, and include studies of mechanisms of oncogenesis and interactions of these agents with host cells. Studies of Chemical Carcinogenesis encompass studies of cancers caused or promoted by chemical or physical agents, acting separately or together, or in combination with biological agents, and their mechanisms of action, as well as basic studies to identify possible targets for preventive or therapeutic measures.
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| PA-06-290 | -Immunoregulation of Gastrointestinal Carcinogenesis |
| PA-06-289 | -Immunoregulation of Gastrointestinal Carcinogenesis |
| PA-07-454 | -Research on Malignancies in the Context of HIV/AIDS (R21) |
| PA-07-455 | -Research on Malignancies in the Context of HIV/AIDS (R01) |
| PA-08-244 | -Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R21) |
| PA-08-243 | -Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R01) |
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| Name | Title |
| Blair, Donald, Ph.D. | Chief |
| Daschner, Phillip J., M.S. | Program Director |
| Poland, Alan P., M.D. | Program Director |
| Read-Connole, Elizabeth, Ph.D. | Program Director |
| Zaika, Ellen | Program Analyst |
| Briggs, Taccara | Extramural Support Asst. |
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| DNA Virus Studies |
Large and small DNA tumor viruses, their mechanisms of transformation and their interactions with their hosts are areas of major emphasis.
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| RNA Virus Studies |
Oncogenic human and animal retroviruses, their oncogenes and etiologic mechanisms, and human and animal hepatitis viruses are studied.
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| AIDS Virus Studies |
Investigations of HIV and related viruses as etiologic agents of AIDS-associated cancers are areas of major interest.
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| Carcinogenic Agents |
Identification of chemical carcinogens, tumor initiators and promoters, and their metabolism, toxicity, and physiologic distribution are studied.
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| Carcinogenic Mechanisms |
Toxicity, mechanisms of action of carcinogenic chemicals and their activation and deactivation pathways, and biochemical and molecular markers of chemical carcinogenesis are investigated.
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| Hormonal Carcinogenesis |
Investigations of the mechanisms involved in endogenous and exogenous hormone-related cancer are supported.
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| Special Activities |
Supports a variety of studies of the mechanisms of bacterial species and chemical and physical agents in the etiology of human cancer.
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| Research Resources |
Supports the synthesis and distribution of chemical carcinogens, mutagens and their metabolites as well as radiochemicals and experimental tumor inhibitors to chemical carcinogenesis investigators.
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