Administrative Supplement Request for Equipment

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Administrative Supplement Request for Equipment
ADMINISTRATIVE SUPPLEMENT REQUEST FOR EQUIPMENT IN SUPPORT OF STUDIES ON TUMOR HOST INTERACTIONS Application Receipt Deadline: June 16, 2003 PURPOSE The National cancer Institute (NCI) invites NCI-funded research grantees to submit equipment requests that will advance the understanding of the molecular and cellular underpinnings of tumor-host interactions. The supplemental program will support equipment in the area of sample preparation, microscopy, and molecular and cellular imaging. Requests for associated software needed for informatics and data analysis for imaging studies can also be included. Studies involving such equipment should help in identifying novel interactions between normal and/or tumor cells with host stroma and eventually have a translational impact. In addition to a strong scientific basis, requests that are accompanied with the relevant documents indicating (i) multi-user involvement, and ii) cost-sharing by the applicants organization will be viewed favorably. Applicant institutions will be expected to support the personnel and other costs associated with the maintenance of equipment. Background and Objectives It is now well recognized that the host environment (tumor microenvironment) is a critical factor in tumor development and that the clinical properties of a tumor, including response to therapy, can be significantly altered by the tumor stroma. However, we have a far more limited understanding of the biology and genetics of the stromal component as compared to that of the tumor cells. The tumor stroma contributes to some of the most destructive characteristics of malignant cells, thus contributing to host morbidity. Besides influencing the cancer cell biology, the microenvironment is an important consideration in cancer treatment as it can influence the access of therapeutics to tumor cells, their metabolism, and the development of drug resistance. Critical stromal elements of the tumor are attractive targets for prevention, because they have a major influence over tumor cells in the early stages of tumor development. Furthermore, they are ideal targets for therapy, as they are genetically more stable than tumor cells and thus less likely to develop drug resistance. Manipulating host-tumor interactions may be important in reverting the malignant phenotype and establishing normal control mechanisms. There have been several recent technological advancements that will facilitate the above-mentioned studies. The applicants can request equipments such as the Laser Capture Microdissection for the isolation of epithelial and stromal cell components, and specialized microscopy equipments such as those used for imaging tumors in vivo and in 3-D models. It is hoped that the integration of equipment will facilitate a better understanding of the molecular interactions between tumor and host cells. Equipment requests associated with microarray analysis or proteomics are outside the scope of this initiative and will not be considered. ELIGIBILITY REQUIREMENTS Only NCI-funded research grantees may submit and be the PI of a supplemental request. The PI must have an active R01, R37, P01, Phased Innovation Award (combined R21/R33), or a SPORE grant (P50) with at least 2 years remaining at the time of anticipated funding date of September 1, 2003 (i.e., the grants must be active until August 31, 2005). All collaborating investigators must have an active source of research funding support from NIH or other funding agencies. Budget/Administrative Issues All funding will be in the form of administrative supplements to existing NCI-funded research grants. The cost of a supplemental equipment request is limited to a maximum of $500,000. However, the number and level of support will depend on the number of meritorious applications received. APPLICATION PROCEDURES AND DEADLINES No specific forms or format are required, although appropriate pages from the PHS 398 form are recommended (see Office of Extramural Research web site for electronic PHS 398 forms. All applications must contain A cover letter listing the eligible parent grant signed by the PI, and collaborating investigators A biosketch for the PI and collaborating investigators. Documentation of active research grant funding A plan (not to exceed 5 typed pages) should include a summary of each collaborators specific contributions to the project and relevance to the study of tumor-host interactions Applications (1 original plus 5 copies) should be sent to: Special Assistant to the Director ATTN: Administrative Supplement Request: Tumor-Host Interaction Division of Cancer Biology National Cancer Institute, NIH, DHHS Executive Plaza North, Room 5048 6130 Executive Boulevard Bethesda, MD 20892-7150 Applications should be received no later than June 16, 2003. Budget start dates should be calculated based on a funding start of September 1, 2003. REVIEW CONSIDERATIONS AND CRITERIA NCI staff will conduct the review. The review criteria are: Strong scientific rationale Multi-user involvement Evidence of institutions commitment including (a) dedicated staff for operating equipment, and b) Cost-sharing by the host institution(s) INQUIRIES NCI-funded investigators who are interested in applying for an supplement request are encouraged to contact: Suresh Mohla, Ph.D. Chief, Tumor Biology & Metastasis Branch Division of Cancer Biology National Cancer Institute 6130 Executive Blvd, EPN 5038 Rockville, MD 20892 301 435 1878 301 480-0864 (FAX) mohlas@mail.nih.gov Grants management related questions or concerns may be directed to: Bill Wells Section Chief, Biology and Population Sciences Section Grants Administration Branch National Cancer Institute, NIH, DHHS Executive Plaza South, Room 243 6120 Executive Boulevard, MSC 7150 Bethesda, MD 20892-7150 Telephone: (301) 496-8796 FAX: (301) 496-8601 E-mail: ww14j@nih.gov

Administrative Supplement Request for Equipment

ADMINISTRATIVE SUPPLEMENT REQUEST FOR EQUIPMENT IN SUPPORT OF STUDIES ON TUMOR HOST INTERACTIONS

Application Receipt Deadline: June 16, 2003

PURPOSE

The National cancer Institute (NCI) invites NCI-funded research grantees to submit equipment requests that will advance the understanding of the molecular and cellular underpinnings of tumor-host interactions. The supplemental program will support equipment in the area of sample preparation, microscopy, and molecular and cellular imaging. Requests for associated software needed for informatics and data analysis for imaging studies can also be included. Studies involving such equipment should help in identifying novel interactions between normal and/or tumor cells with host stroma and eventually have a translational impact. In addition to a strong scientific basis, requests that are accompanied with the relevant documents indicating (i) multi-user involvement, and ii) cost-sharing by the applicants organization will be viewed favorably. Applicant institutions will be expected to support the personnel and other costs associated with the maintenance of equipment.

Background and Objectives

It is now well recognized that the host environment (tumor microenvironment) is a critical factor in tumor development and that the clinical properties of a tumor, including response to therapy, can be significantly altered by the tumor stroma. However, we have a far more limited understanding of the biology and genetics of the stromal component as compared to that of the tumor cells. The tumor stroma contributes to some of the most destructive characteristics of malignant cells, thus contributing to host morbidity. Besides influencing the cancer cell biology, the microenvironment is an important consideration in cancer treatment as it can influence the access of therapeutics to tumor cells, their metabolism, and the development of drug resistance. Critical stromal elements of the tumor are attractive targets for prevention, because they have a major influence over tumor cells in the early stages of tumor development. Furthermore, they are ideal targets for therapy, as they are genetically more stable than tumor cells and thus less likely to develop drug resistance. Manipulating host-tumor interactions may be important in reverting the malignant phenotype and establishing normal control mechanisms.

There have been several recent technological advancements that will facilitate the above-mentioned studies. The applicants can request equipments such as the Laser Capture Microdissection for the isolation of epithelial and stromal cell components, and specialized microscopy equipments such as those used for imaging tumors in vivo and in 3-D models. It is hoped that the integration of equipment will facilitate a better understanding of the molecular interactions between tumor and host cells. Equipment requests associated with microarray analysis or proteomics are outside the scope of this initiative and will not be considered.

ELIGIBILITY REQUIREMENTS

Only NCI-funded research grantees may submit and be the PI of a supplemental request. The PI must have an active R01, R37, P01, Phased Innovation Award (combined R21/R33), or a SPORE grant (P50) with at least 2 years remaining at the time of anticipated funding date of September 1, 2003 (i.e., the grants must be active until August 31, 2005). All collaborating investigators must have an active source of research funding support from NIH or other funding agencies.

Budget/Administrative Issues

All funding will be in the form of administrative supplements to existing NCI-funded research grants. The cost of a supplemental equipment request is limited to a maximum of $500,000. However, the number and level of support will depend on the number of meritorious applications received.

APPLICATION PROCEDURES AND DEADLINES

No specific forms or format are required, although appropriate pages from the PHS 398 form are recommended (see Office of Extramural Research web site for electronic PHS 398 forms.

All applications must contain

A cover letter listing the eligible parent grant signed by the PI, and collaborating investigators
A biosketch for the PI and collaborating investigators.
Documentation of active research grant funding
A plan (not to exceed 5 typed pages) should include a summary of each collaborators specific contributions to the project and relevance to the study of tumor-host interactions

Applications (1 original plus 5 copies) should be sent to:

Special Assistant to the Director
ATTN: Administrative Supplement Request: Tumor-Host Interaction
Division of Cancer Biology
National Cancer Institute, NIH, DHHS
Executive Plaza North, Room 5048
6130 Executive Boulevard
Bethesda, MD 20892-7150

Applications should be received no later than June 16, 2003. Budget start dates should be calculated based on a funding start of September 1, 2003.

REVIEW CONSIDERATIONS AND CRITERIA

NCI staff will conduct the review. The review criteria are:

Strong scientific rationale
Multi-user involvement
Evidence of institutions commitment including (a) dedicated staff for operating equipment, and b) Cost-sharing by the host institution(s)

INQUIRIES

NCI-funded investigators who are interested in applying for an supplement request are encouraged to contact:

Suresh Mohla, Ph.D.
Chief, Tumor Biology & Metastasis Branch
Division of Cancer Biology
National Cancer Institute
6130 Executive Blvd, EPN 5038
Rockville, MD 20892
301 435 1878
301 480-0864 (FAX)
mohlas@mail.nih.gov

Grants management related questions or concerns may be directed to:

Bill Wells
Section Chief, Biology and Population Sciences Section
Grants Administration Branch
National Cancer Institute, NIH, DHHS
Executive Plaza South, Room 243
6120 Executive Boulevard, MSC 7150
Bethesda, MD 20892-7150
Telephone: (301) 496-8796
FAX: (301) 496-8601
E-mail: ww14j@nih.gov

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