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The National Cancer Institute’s Mouse Models of Human Cancer Consortium (NCI-MMHCC) is a collaborative program designed to develop ways to apply Genetically Engineered Mouse Models (GEMMs) for translational science; preclinical and co-clinical drug testing, prevention research, susceptibility determination, and biomarker discovery. Funded by the NCI since 2000, the NCI-MMHCC has significantly advanced the science of in vivo and in vitro cancer modeling by deriving cancer-prone models through altering germlines of laboratory mice, developing a variety of organotypic co-culture systems, and grafting human tissues into immuno-compromised mice.  The 25 groups who comprise the Consortium more than 300 members at 50 institutions, including the NCI Center for Cancer Research in the US and abroad are experts in many aspects of basic, translational, and clinical cancer research, in engineering the mouse germline to simulate human cancers, and in using inbred mouse strains as models for human cancer susceptibility.

For more information about the program, please visit the MMHCC website.

The Integrative Cancer Biology Program (ICBP) focuses on the analysis of cancer as a complex biological system.  A cornerstone of the program is the development and implementation of computational models of processes relevant to cancer prevention, diagnostics and therapeutics.  The integration of experimental biology with mathematical modeling will result in new insights in the biology and new approaches to the management of cancer.  The program brings clinical and basic cancer researchers together with researchers from mathematics, physics, information technology, imaging sciences, and computer science to work on key questions in cancer biology.

For more information about this program, please visit the ICBP website.

The Tumor Microenvironment Network (TMEN) initiative focuses on expanding our understanding of the role of the tumor microenvironment in cancer initiation, progression and metastases. Through this initiative, NCI intends to generate a more comprehensive understanding of  the composition of the stroma in normal tissues, with the goal of delineating the mechanisms of tumor-stromal interactions in human cancer.

For more information about this program, please visit the TMEN website.

The Barrett’s Esophagus Translational Research Network (BETRNet) program is a trans-divisional NCI program that is supported by the Division of Cancer Biology and the Division of Cancer Prevention.  The objectives of BETRNet are to achieve a better understanding of esophageal adenocarcinoma (EA) biology, examine research opportunities associated with it’s only accepted precursor lesion Barrett’s Esophagus, improve EA risk stratification and prediction, and provide strategies for EA prevention.  The overriding goal is to decrease the incidence, morbidity and mortality of one of the fastest growing cancers in the United States.


For more information about this program, please visit the BETRNet website (coming soon).