The DNA and Chromosome Aberrations Branch (DCAB) plans and administers a broadly-based extramural program of grants in the area of cancer genetics and epigenetics, including regulation of gene expression, mechanisms of DNA damage/repair, genomic instability and related molecular, cytogenetic, and chromosomal effects during induction and progression to malignancy.
Chemical and structural modifications of DNA, transcriptional regulation, chromatin modifications, nuclear architecture; role of ncRNAs; epigenetic mechanisms.
Cytogenetic and Molecular Structure/Function Analysis
Cytogenetic and molecular structure/function analysis of induced and spontaneous chromosome aberrations that are associated with genomic instability and cancer induction (e.g., translocations, amplifications, deletions, fragile sites).
Mapping and characterization of new cancer genes.
Biochemistry, Molecular Biology, and Structural Biology of Carcinogens
Carcinogen-induced (e.g., radiation, chemicals, etc.) and endogenous DNA repair mechanisms (e.g., nucleotide and base excision, recombination, mismatch repair pathways).
Mechanisms of DNA Damage and Repair
Mechanisms of DNA damage-inducible signaling, resulting perturbations to the cell-cycle, and regulation of apoptosis or other mechanisms of programmed cell death.